Table 4.

Genotypes affecting mercaptopurine-related neutropenia according to multivariate analysis

Variable	HR	95% CI	p-value
APEX1 rs2307486
AA genotypes (wild type)	1.00	-	-
AG genotypes	1.49	0.87-2.53	0.139
GG genotypes	12.03	1.43-101.20	0.022
NUDT15 rs116855232
CC genotypes (wild type)	1.00	-	-
CT genotypes	1.25	0.78-2.01	0.358
TT genotypes	11.42	3.35-38.97	< 0.001
ABCC4 rs3765534
CC genotypes (wild type)	1.00	-	-
CT genotypes	1.72	1.05-2.80	0.031
TT genotypes	2.11	0.62-7.20	0.232

HR, hazard ratio; CI, confidence interval.