Fig. 5.

Snail-overexpressed fibroblasts induce 5-fluorouracil (5-FU)/paclitaxel (PTX) resistance in the subcutaneous transplanted in BABL/c mice. (A) Treatment protocol of scheduling administration of 5-FU (30 mg/kg)/PTX (15 mg/kg) in tumorbearing mice by tail vein injection. (B, C) Tumor growth curves showed that tumors grew much slower in groups of tumor CT26 cells alone and CT26 cells mixed with 3T3-mock treated with 5-FU or PTX than the groups without treatment (n=5, *p < 0.05). (D) Meanwhile, tumor grew without any restriction in the groups of 3T3-Snail mixed with CT26 tumor cells.