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. 2017 Sep 18;50(3):894–907. doi: 10.4143/crt.2017.356

Fig. 8.

Fig. 8.

Chemokine (C-C motif) ligand 1 (CCL1) contribute to chemoresistance in CT26 via transforming growth factor β (TGF-β) and nuclear factor кB (NF-кB) signaling pathways. (A) CT26 cells were treated with CCL1 for 5 minutes, 15 minutes, 30 minutes, and 1 hour, and the key proteins of several signaling pathways were detected via western blotting. (B) CT26 cells were pretreated with or without SB431542 (20 μM), BAY11-7081 (10 μM) for 2 hours and treated with CCL1 (100 ng/mL) for 48 hours, and then the expression of multidrug resistance protein 1 (MDR1) was analyzed by western blot. (C, D) Cells were pretreated with or without SB431542 (20 μM) (C)/BAY11-7081 (10 μM) (D) for 2 hours and treated with or without CCL1 (100 ng/mL) for 5 minutes, and TGF-β, NF-кB pathway key proteins were analyzed by western blot. GAPDH, glyceraldehyde 3-phosphate dehydrogenase.