Table 2.
Asparaginase-related toxicity per patient
| IMEP+L (n=22) | IMEP+P (n=19) | p-value | |
|---|---|---|---|
| Asparaginase-related toxicity (all grades) | |||
| AST elevation | 10 (45.5) | 9 (47.4) | 0.902 |
| ALT elevation | 11 (50.0) | 12 (63.2) | 0.397 |
| ALP elevation | 8 (36.4) | 11 (57.9) | 0.168 |
| t-bil elevation | 13 (59.1) | 8 (42.1) | 0.278 |
| Hypoalbuminemia | 16 (72.7) | 13 (68.4) | 0.763 |
| Hypofibrinogenemia | 19 (86.4) | 7 (36.8) | 0.001 |
| Hyperglycemia | 5 (22.7) | 1 (5.3) | 0.112 |
| Hypertriglycemia | 6 (27.3) | 4 (21.1) | 0.727 |
| Pancreatitis | 1 (4.5) | 2 (10.5) | 0.588 |
| Allergy | 7 (31.8) | 3 (15.8) | 0.366 |
| Asparaginase-related toxicity (≥ grades 3) | |||
| AST elevation | 3 (13.6) | 2 (10.5) | > 0.99 |
| ALT elevation | 1 (4.5) | 2 (10.5) | 0.588 |
| ALP elevation | 1 (4.5) | 0 | > 0.99 |
| t-bil elevation | 2 (9.1) | 0 | 0.490 |
| Hypoalbuminemia | 1 (4.5) | 1 (5.3) | > 0.99 |
| Hypofibrinogenemia | 3 (13.6) | 3 (15.8) | > 0.99 |
| Allergy | 2 (9.1) | 1 (5.3) | 0.485 |
IMEP+L/P, ifosfamide, mesna, etoposide, prednisolone+L-asparaginase/peg-asparaginase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; t-bil, total bilirubin.