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Effects of NicA2-ABD on NSA during unlimited access to nicotine. Mean (± SD) number of infusions during 23-h access following pretreatment with PBS vehicle (V) and NicA2-ABD over six consecutive test sessions, expressed as a percentage of baseline. Each point represents the mean of four rats. The dotted horizontal line represents baseline. The dashed horizontal line represents the 50% reduction criterion for extinction. Different from V, **p < 0.01, ***p < 0.001
