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. 2018 Jul 24;18:46. doi: 10.1186/s12896-018-0457-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — NicA2 effects on nicotine or sucrose self-administration. Mean (± SD) nicotine self-administration (infusion rate) and sucrose-maintained responding (pellet delivery rate) following pretreatment with PBS vehicle (V) and NicA2 over four consecutive test sessions, expressed as a percentage of baseline. A total of 8 rats responding for nicotine were treated with NicA2. Of these, 5 showed a decrease in NSA (Panel a; Decreasers) and 3 showed an increase in NSA (Panel b; Compensators). Two of these “compensators” were allowed to re-establish baseline NSA and were then treated with 70 mg/kg NicA2 (Panel b). Five additional rats responded for sucrose and received NicA2 (Panel a). The dotted horizontal line represents baseline. The dashed horizontal line represents the 50% reduction criterion for extinction