Table 8.
Characterization of UTI isolates
| Strain | Resistance profile | Phylo-group | PMQR genes | QRDR mutations | β-lactamase-resistance-genes | Other resistant genes | Integron | |
|---|---|---|---|---|---|---|---|---|
| ∆GyrA | ∆ParC | |||||||
| UEc 11 | AMP, SXT | B2 | NA | NA | bla TEM | ant(3″)-Ia (aadA1), aph3 (strA), dhfrI, sulII, tet(B) | Class 2 integron | |
| UEc 22 | AMP, SAM, AMC, CFZ, SXT, CIP, LEV, NOR | B2 | S83 → L D87 → N |
S80 → I T66 → N |
bla TEM | tet(B) | ||
| UEc 23 | AMP, SAM, CFZ, CTZ, CAZ, CRO, FEP, SXT, CIP, LEV | F | aac(6′)-Ib-cr | NA | NA | aac(3)-IIa (aacC2) | Class 1 integron | |
| UEc 27 | GEN, AMP, SAM, AMC, SXT, CIP, LEV | B2 | S83 → L D87 → N |
S80 → I E84 → V |
bla PSE-1 | sulI, tet(A) | ||
| UEc 30 | GEN, SAM, AMC, SXT | B2 | NA | NA | bla OXA-1 | ant(3″)-Ia (aadA1), tet(A), tet(30), tet®, sulI | Class 1 integron | |
| UEc 58 | AMP, SXT, CIP, LEV | B2 | S83 → L D87 → N G114 → S |
S80 → I | bla TEM | dhfrVII, sulII, tet(B), aph3 (strA), mphA | ||
| UEc 65 | AMP, CFZ, CAZ, CRO, FEP, CIP, LEV | D | S83 → L D87 → N G114 → S |
S80 → I |
bla
CTX-M-15
bla TEM |
aac(3)-IIa (aacC2), dhfrVII, mphA, sulI, tet(B) | Class 1 integron | |
| UEc 69 | AMP, SXT, NIT | B2 | qnrA | NA | NA | bla TEM | sulII | |
| UEc 75 | AMK, GEN, AMP, SAM, AMC, TZP, CFZ, CTX, CRO, FEPCIP, LEV, NOR | B2 | qnrA | S83 → L D87 → N |
S80 → I T66 → Y |
blaOXY/K1, blaTEM | aac(3)-IIa (aacC2), aph(3′)-Ia (aphA1), aph(3′)-IIa (aphA2), aph3 (strA), sulI, sulII, tet(A), tet(B) | |
| UEc 76 | CFZ, CAZ, CRO, FEP, CIP, LEV | B2 | S83 → L D87 → N |
S80 → I T66 → Y E84 → V |
bla
CTX-M-15
bla OXA-1 |
tet(A), tet(30) | ||
| UEc 84 | GEN, TOB, AMP, SAM, TZP, CFZ, CTX, CAZ, CRO, FEP, SXT, CIP, LEV | D | aac(6′)-Ib-cr | S83 → L D87 → N |
S80 → I |
blaCTX-M-15, blaOXA-1 bla TEM bla PSE-4 |
tet(30), mphA | |
| UEc 99 | AMP, SXT | B2 | qnrA | None | None |
blaCTX-M-12, blaOXA-9, blaTEM |
aac(3)-IV, aac(3)-IIa (aacC2), aph3 (strA), catI, sulI, sulII | Class 1 integron |
| UEc 102 | AMP, CFZ, CAZ, CRO, FEP, SXT, CIP, LEV | B2 | S83 → L D87 → N G114 → S |
S80 → I | bla TEM | aph(3′)-Ia (aphA1), sulII | ||
| UEc 104 | AMP, SXT | D | qnrA, aac(6′)-Ib-cr | NA | NA |
blaCMY-2, blaCTX-M-12, blaOXA-1 |
aac(3)-IIa (aacC2), sulI, tet(B), mphA | Class 1 integron |
| UEc 107 | F | NA | NA | |||||
| UEc 108 | AMP | D | qnrA | NA | NA | bla TEM | sulI | Class 1 integron |
| UEc 109 | AMP, SAM | D | aac(6′)-Ib-cr | NA | NA | bla TEM | sulII | |
| UEc 110 | GEN, TOB, AMP, SAM, CTX, SXT, CIP, NIT | B2 | NA | NA | aac(3)-IIa (aacC2), tet(B) | Class 1 integron | ||
AMK Amikacin, GEN gentamicin, TOB tobramycin, NET netilmicin, AMP ampicillin, SAM ampicillin–sulbactam, AMC amoxicillin–clavulanic acid, TZP piperacillin–tazobactam, CFZ cefazolin, CTX cefotaxime, CAZ ceftazidime, CRO ceftriaxone, FEP cefepime; SXT trimethoprim–sulfamethoxazole, CIP ciprofloxacin, LEV levofloxacin, NOR norfloxacin, NIT nitrofurantoin, ETP ertapenem, IPM imipenem, PMQR plasmid-mediated quinolone resistance genes, QRDR quinolone resistance-determining region, NA not analyzed