Table 1.

Forbidden and restricted medication in the trial

Forbidden medication	Cholinesterase inhibitors
	N-methyl-D-aspartate (NMDA) antagonists
	Synthetic adrenal corticosteroids
	Central nervous system stimulants
	Chinese and western cognitive improvement medication
Restricted medicationa	Antipsychotics
	Antidepressants
	Sedative-hypnoticsb

Restricted medication^a: The dose of these medications should not be increased during the trial. Patients with these medications for a long time should keep the dose stable

Sedative-hypnotics^b: If necessary, temporary use of zopiclone, alprazolam or estazolam is allowed. Last dose before psychological assessment should not be given later than 22:00 last night