Table 3.
Correlation analysis between non-synonymous mutations of all targeted genes of CAGE and baseline characteristics in the 46 patients with oral squamous cell carcinoma
| Characteristics | Total patients N = 46 | Non-synonymous mutations | P value* | |
|---|---|---|---|---|
| + | – | |||
| n (%) | n (%) | n (%) | ||
| Gender | ||||
| Male | 12 (26.1) | 10 (25.0) | 2 (33.3) | 0.644 |
| Female | 34 (73.9) | 30 (75.0) | 4 (66.7) | |
| Age (years) | ||||
| < 60 | 27 (58.7) | 23 (57.5) | 4 (66.7) | 1.000 |
| ≥ 60 | 19 (41.3) | 17 (42.5) | 2 (33.3) | |
| Site | ||||
| Tongue | 19(41.3) | 18(45.0) | 1(16.7) | 0.182 |
| Buccal | 6(13.0) | 6(15.0) | 0(0.0) | |
| Gingiva | 6(13.0) | 5(12.5) | 1(16.7) | |
| Floor of mouth | 3(6.5) | 2(5.0) | 1(16.7) | |
| Palate | 9(19.6) | 6 (15.0) | 3 (50.0) | |
| Retromolar trigone | 3(6.5) | 3(7.5) | 0(0.0) | |
| Clinical T stage | ||||
| T1/T2 | 13(28.3) | 11(27.5) | 2(33.3) | 1.000 |
| T3/T4 | 33 (71.7) | 29(72.5) | 4(66.7) | |
| Clinical N stage | ||||
| N0 | 14(30.4) | 11(27.5) | 3 (50.0) | 0.633 |
| N1 | 12(26.1) | 11(27.5) | 1(16.7) | |
| N2 | 20(43.5) | 18(45.0) | 2(33.3) | |
| Clinical stage | ||||
| III | 22(47.8) | 19(47.5) | 3 (50.0) | 1.000 |
| IVA | 24(52.2) | 21(52.5) | 3 (50.0) | |
| Pathological differentiation grade | ||||
| Well | 13(28.3) | 11(27.5) | 2(33.3) | 1.000 |
| Moderately/Poorly | 33(71.7) | 29(72.5) | 4(66.7) | |
| Smoking statusa | ||||
| Current/former | 19(41.3) | 17(42.5) | 2(33.3) | 1.000 |
| Never | 27(58.7) | 23 (57.5) | 4(66.7) | |
| Alcohol useb | ||||
| Positive | 24(52.2) | 22(55.0) | 2(33.3) | 0.405 |
| Negative | 22(47.8) | 18(45.0) | 4(66.7) | |
*P value from the chi-square test was reported to compare the difference between the patients with and without non-synonymous mutation of targeted genes based on different baseline characteristics
aFormer/current smokers defined as at least a one pack-year history of smoking
bPositive alcohol use was defined as current alcohol use of more than one drink per day for 1 year (12 oz of beer with 5% alcohol, or 5 oz of wine with 12–15% alcohol, or one ounce of liquor with 45–60% alcohol). All other patients were classified as negative alcohol use
Note: No significant correlation was found between the non-synonymous mutant status of all targeted genes of CAGE and baseline characteristics in the 46 patients with oral squamous cell carcinoma