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. 2018 Jul 24;13:38. doi: 10.1186/s13024-018-0272-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Analysis of GRS vs. aggregate AD-related pathologies and microglial density. Immunohistochemistry images showing (a) neuritic amyloid plaques (stained with 4G8), (b) neurofibrillary (tau) tangles (stained with AT8), and (c) microglia at three stages of activation (stained with CR3–43) in our postmortem tissue samples. (d) Two-sided uncorrected P-values derived from robust regression are shown within tiles. Models co-varied for age at death, sex, and three EIGENSTRAT principal components. The color scale indicates magnitude and direction of the effect T-statistic. *significant after FDR correction (P_FDR < 0.05)