Table 1.
Survey of DHPS variants and known resistance to sulfonamides.
|
Sequence Background |
25923 | 8325* | 8325 | 25923 | 8325 | 8325 | 25923 | 8325 | 25923 | 8325 |
|---|---|---|---|---|---|---|---|---|---|---|
| Resistance Mutations | None | None | F17L KE257_dup |
T51M E208K |
T51M E208K |
F17L E208K |
F17L | F17L | T51M | S18L |
| % Sequences (n = 136) |
28 | 49 | 3 | 8 | 1.5 | 3.7 | 3 | 2 | 0.7 | 0.7 |
| Hampele Strain |
Group 1 | Group 2 | Group 3 | Group 4 | ||||||
| Hampele MIC (μg/mL) | 256–>1024 | 256–>1024 | >1024 | >1024 | ||||||
| Sulfonamide resistant | No | No | Yes | Yes | Yes | Yes | ND | ND | ND | ND |
Hampele strain group and MIC values have previously been published (Hampele et al., 1997).
*
Indicates that among the wild type folP genes surveyed and categorized as having an 8325 background, 31% lacked the natural variations T59S and L64M seen in the S. aureus strain Rosenbach 25923 (Supplementary Table 1).