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. Author manuscript; available in PMC: 2018 Jul 24.
Published in final edited form as: Results Probl Cell Differ. 2017;61:83–114. doi: 10.1007/978-3-319-53150-2_4

Figure 2.

Figure 2

Asymmetric cell division in C. elegans. (A) A Wnt signal from P2 polarizes EMS, which divides into endoderm (E) and mesoderm (MS) daughter cells. E displays lowered nuclear POP-1 (blue cross-hatching) and elevated SYS-1 compared to MS. (B) Z1/Z4 somatic gonadal precursor cells divide along the proximal-distal axis (dashed line), each asymmetrically generating a distal tip cell (DTC) lineage daughter and a proximal anchor cell potential lineage. (C) A newly hatched worm contains several seam cells on both sides of the worm. Most seam cells (H1–H2, V1–V6) divide in a stem cell-like manner giving rise to a seam cell daughter and a terminally differentiates hypodermal daughter at each larval molt. In each case (A–C), WβA signaling activates a transcriptional profile specific for the signaled daughter that is repressed in the unsignaled daughter. A symmetric cell division at L2 increases overall seam cell number to 16. Modified from Phillips and Kimble 2007.