Skip to main content
. Author manuscript; available in PMC: 2018 Jul 24.
Published in final edited form as: Results Probl Cell Differ. 2017;61:83–114. doi: 10.1007/978-3-319-53150-2_4

Figure 3.

Figure 3

Model of WβA-controlled asymmetric division. Two separate branches of the pathway, the WRM-1-regulating (blue) and the SYS-1 regulating (red) are balanced by Dishevelled (Dvl) and together generate transcriptional asymmetry in daughter cells following division. The activity of posterior factors including Frizzled and Dishevelled restrict cortical localization or activity of negative factors APC and Axin. In addition, Dishevelled distinguishes between two pools of APC in the unsignaled cell to modulate each downstream branch of the pathway. One pool of APC stabilizes microtubules (MTs) to promote WRM-1/β-catenin (W) export, which results in high nuclear POP-1/TCF (P). The other pool of APC degrades SYS-1/β-catenin in concert with KIN-19/CKIα (CK). Target genes are repressed. In the signaled daughter cell (right), neither pool of APC exists so WRM-1 and SYS-1 are both high. POP-1 is low because of nuclear export, mediated by phosphorylation by LIT-1 (L) through association with WRM-1. Target genes are expressed. Modified version of Baldwin et al 2016.