. Author manuscript; available in PMC: 2018 Jul 24.

Published in final edited form as: J Neurochem. 2017 Aug;142(Suppl 2):151–161. doi: 10.1111/jnc.14010

Table 2.

Changes in nicotinic ligand binding in granulocytes of smokers compared to non-smokers

[³H]-Nicotine	[³H]-Epibatidine	[¹²⁵I]-α-bungarotoxin	Reference
Increase			Lebargy et al. 1996, Benhammou et al. 2000
	Increase	(N.S.)	Cormier et al. 2004

N.S., not significant.

Effects of smoking on nicotine, epibatidine, and α-bgtx binding. Nicotine and epibatidine primarily bind to α3*, α4*, β2*, and β4* nAChRs while α-bgtx binds to α7-nAChRs selectively. Comparing granulocytes of smokers to non-smokers, increases in binding were observed for both nicotine and epibatidine, but no increase in binding was observed for α-bgtx.