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. 2018 Jul 15;34(3):191–197. doi: 10.5487/TR.2018.34.3.191

Table 3.

Results of collaborative study for the 1 TD of lethal titer and hemorrhagic titer determination

Test 1 TD of Lethal titer (μg) 1 TD of Hemorrhagic titer (μg)

1* 2 3 4§ 5|| 1* 2 3 4§
1 94.20 103.77 94.20 107.92 85.86 8.50 12.18 11.28 11.08
2 78.58 94.20 94.20 107.92 102.65 8.87 10.99 11.44 8.99
3 86.37 86.37 96.00 107.92 96.00 10.13 10.48 11.33 9.14
4 68.37 94.20 96.00 86.37 89.78 8.67 10.81 11.26 9.69
5 78.58 78.58 94.20 86.37 89.78 9.41 10.70 10.78 10.11
6 94.20 94.35 86.37 10.87 12.23 11.40
7 86.37 94.20 86.37 11.36 11.19 11.84
8 94.20 96.00 86.37 11.19 10.89 11.81
9 98.23 86.37 94.20 10.22 10.65 9.73
10 96.00 78.58 94.20 10.94 11.38 11.38
Common potency (%) 87.51 90.66 92.21 99.30 92.81 10.02 11.15 11.23 9.80
95% confidence interval 81.49 85.69 89.67 88.95 87.04 9.34 10.77 10.85 9.06
~93.53 ~95.64 ~94.75 ~109.65 ~98.59 ~10.69 ~11.53 ~11.60 ~10.54
Coefficients of variation 11.10 8.86 4.44 11.89 7.10 10.84 5.51 5.37 8.59
General common potency 90.13 - - 10.80 -
*

National Institute of Food and Drug Safety Evaluation (NIFDS), Cheongju, Korea.

Osong Medical Innovation Foundation (KBIO), Cheongju, Korea.

Koreavaccine co., Ansan, Korea.

§

National Institute of Infectious Diseases (NIID), Tokyo, Japan.

||

National Quality Control Laboratory of Drug and Food (NQCLDF), Central Jakarta, Indonesia.

Titers are expressed as μg per animal. Standardization of NRS for Snake Venom in Korea 195