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. 2018 Jul 15;34(3):191–197. doi: 10.5487/TR.2018.34.3.191

Table 4.

Results of collaborative study for lethal toxicity and minimal hemorrhagic dose (MHD)

Test Lethal toxicity (μg)|| Minimal hemorrhagic dose (MHD) (μg)||

1* 2 3 4§ 1* 2 3 4§
1 28.28 28.28 28.28 27.32 0.64 1.11 0.64 0.29
2 25.94 25.94 28.28 28.28 1.48 1.90 0.48 0.45
3 28.28 28.28 28.28 28.30 0.82 0.91 0.79 0.39
Common potency 27.50 27.50 28.28 27.97 0.98 1.31 0.64 0.38
95% confidence interval 25.97 25.97 - 27.33 0.48 0.71 0.46 0.28
~29.03 ~29.03 ~28.60 ~1.48 ~1.90 ~0.81 ~0.47
Coefficients of variation (%) 4.92 4.91 - 2.00 44.72 40.33 24.21 21.48
*

National Institute of Food and Drug Safety Evaluation (NIFDS), Cheongju, Korea.

Osong Medical Innovation Foundation (KBIO), Cheongju, Korea.

Koreavaccine co., Ansan, Korea.

§

National Institute of Infectious Diseases (NIID), Tokyo, Japan.

||

Titers are expressed as μg per animal.