Table 4.
Test | Lethal toxicity (μg)|| | Minimal hemorrhagic dose (MHD) (μg)|| | ||||||
---|---|---|---|---|---|---|---|---|
| ||||||||
1* | 2† | 3‡ | 4§ | 1* | 2† | 3‡ | 4§ | |
1 | 28.28 | 28.28 | 28.28 | 27.32 | 0.64 | 1.11 | 0.64 | 0.29 |
2 | 25.94 | 25.94 | 28.28 | 28.28 | 1.48 | 1.90 | 0.48 | 0.45 |
3 | 28.28 | 28.28 | 28.28 | 28.30 | 0.82 | 0.91 | 0.79 | 0.39 |
Common potency | 27.50 | 27.50 | 28.28 | 27.97 | 0.98 | 1.31 | 0.64 | 0.38 |
95% confidence interval | 25.97 | 25.97 | - | 27.33 | 0.48 | 0.71 | 0.46 | 0.28 |
~29.03 | ~29.03 | ~28.60 | ~1.48 | ~1.90 | ~0.81 | ~0.47 | ||
Coefficients of variation (%) | 4.92 | 4.91 | - | 2.00 | 44.72 | 40.33 | 24.21 | 21.48 |
National Institute of Food and Drug Safety Evaluation (NIFDS), Cheongju, Korea.
Osong Medical Innovation Foundation (KBIO), Cheongju, Korea.
Koreavaccine co., Ansan, Korea.
National Institute of Infectious Diseases (NIID), Tokyo, Japan.
Titers are expressed as μg per animal.