Table 1.
Changes in gene expression in neutrophils phagocytizing iRBCs as determined by DNA microarray analysis and qRT-PCR.
| Gene | GenBank accession number | Fold change† | |
|---|---|---|---|
| Microarray | qRT-PCR | ||
| RIT2 | NM_002930 | 780.63 | 51.35 ± 14.44 |
| MLLT10 | NM_004641 | 287.92 | 6.20 ± 2.67 |
| CTSL | NM_001912 | 87.55 | 41.10 ± 26.38 |
| CYGB | NM_134268 | 39.87 | 9.65 ± 5.92 |
| ELN | NM_000501 | 39.86 | 30.72 ± 19.00 |
| SOCS3 | NM_003955 | 37.19 | 6.90 ± 2.70 |
| IRG1 | NM_001258406 | 22.05 | 5.39 ± 1.80 |
| VIT | NM_053276 | 18.94 | 8.41 ± 4.30 |
| CISH | NM_145071 | 18.19 | 24.65 ± 3.22 |
| CXCL10 | NM_001565 | 17.69 | 10.83 ± 7.63 |
| CD64 | XM_005244958 | 10.56 | 8.24 ± 1.30 |
†Fold change indicates the mean expression level of the gene in neutrophils cocultured with Plasmodium falciparum-parasitized erythrocytes normalized to that in neutrophils cocultured with normal red blood cells.