Table 5.
Effect of the extracts on biochemical parameters of mice in chronic toxicity test.
| Parameters | Extracts | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Control | AGDC | % | AGET | % | TCDC | % | TCET | % | |
| 166 mg/kg | change | 193 mg/kg | change | 189 mg/kg | change | 170 mg/kg | change | ||
| AST(U/l) | 102.75 ± 5.21 | 128.25 ± 6.10∗ | 26↑ | 134.0 ± 4.14∗∗ | 31↑ | 98.45 ± 5.18 | 4↓ | 131.0 ± 5.36∗∗ | 28↑ |
| ALT(U/l) | 30.62 ± 2.14 | 47.97 ± 1.42∗∗∗ | 56↑ | 53.92 ± 4.45∗∗ | 76↑ | 26.7 ± 1.64 | 13↓ | 39.62 ± 2.93 | 35↑ |
| GGT(U/l) | 4.75 ± 0.15 | 6.72 ± 0.23∗∗∗ | 42↑ | 5.75 ± 0.29∗ | 21↑ | 3.12 ± 0.08∗∗∗ | 34↓ | 4.6 ± 0.28 | 3↓ |
| ALP(U/l) | 320.75 ± 9.64 | 414.0 ± 8.39∗∗∗ | 29↑ | 425.0 ± 6.64∗∗∗ | 32↑ | 347.50 ± 7.55 | 8↑ | 385.5 ± 6.06∗ | 12↑ |
| Bilirubin(mg/dl) | 0.52 ± 0.01 | 0.77 ± 0.01∗∗∗ | 47↑ | 0.71 ± 0.02∗∗ | 36↑ | 0.50 ± 0.01 | 0.68 ± 0.02∗∗ | 30↑ | |
| Glucose(mg/dl) | 122.0 ± 4.88 | 196.25 ± 7.18∗∗∗ | 61↑ | 136.25 ± 6.26 | 11↑ | 77.90 ± 0.02∗∗ | 36↓ | 123.50 ± 8.45 | |
| Sodium (mEq/L) | 84.18 ± 1.97 | 107.14 ± 2.8∗∗∗ | 27↑ | 99.10 ± 2.36∗∗ | 17↑ | 117.47 ± 3.9∗∗ | 40↑ | 105.99 ± 1.9∗∗∗ | 26↑ |
| Potassium (mEq/L) | 5.0 ± 0.02 | 7.22 ± 0.28∗∗∗ | 45↑ | 6.97 ± 0.11∗∗∗ | 40↑ | 6.6 ± 0.12∗∗∗ | 32↑ | 5.60 ± 0.12 | 12↑ |
| Calcium (mg/dl) | 7.42 ± 0.59 | 5.61 ± 0.66 | 24↓ | 5.52 ± 0.65 | 26 | 5.23 ± 0.42∗ | 29↓ | 6.95 ± 0.47 | 6↓ |
| Urea (nmol/l) | 39.1 ± 1.78 | 38.95 ± 1.41 | 29.92 ± 3.50 | 23↓ | 59.35 ± 4.26∗∗ | 52↑ | 65.0 ± 3.53∗∗∗ | 66↑ | |
| Uric acid (mg/dl) | 6.97 ± 0.25 | 4.95 ± 0.09∗∗∗ | 29↓ | 8.87 ± 0.30∗∗ | 27↑ | 6.87 ± 0.30 | 10.27 ± 0.45∗∗∗ | 47↑ | |
| Creatinine (mg/dl) | 0.92 ± 0.04 | 1.01 ± 0.04 | 9↑ | 1.27 ± 0.02∗∗∗ | 38↑ | 1.44 ± 0.02∗∗∗ | 56↑ | 1.52 ± 0.09∗∗∗ | 65↑ |
All values represent mean ± SEM. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ANOVA, followed by Dunnett's multiple comparison test. Test value compared with control group