(A) All patients were classified into two groups “Cytoplasm High/ Cytoplasm Low” according to the expression of cytoplasm: the high group of AQP1 expression in the cytoplasm (n=34, solid line) and the low group of AQP1 expression in the cytoplasm (n=16, doted line). (B) All patients were classified into two groups “Nuclear membrane High/ Nuclear membrane Low” according to the expression of nuclear membrane: the high group of AQP1 expression (n=15, solid line) and the low group of AQP1 expression (n=35, doted line) in the nuclear membrane. (C) All patients were classified into two groups according to both cytoplasm and nuclear membrane: a “Cytoplasm dominant” group (n=20, solid line) and an Others group (n=30, doted line). *p<0.05: Log-rank test.