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. 2018 Jul 6;9(52):29869–29876. doi: 10.18632/oncotarget.25581

Figure 1. Vector constructs and their influence on apoptosis of CD34+ cells.

Figure 1

(A) Overview of the workflow. (B) Under stress conditions apoptosis rate of CD34+ cells transduced with shTP53 is significantly lower than in CD34+ cells transduced with shScr or in non-transduced cells. (C) Under stress conditions CD34+ cells over-expressing wtTP53 have significantly higher apoptosis rates in comparison to controls and to cells with TP53 mutations R175H, R248W and R249S. (*P < 0.05; **P < 0.01; ***P < 0.001).