Table 2. Multivariate analysis of prognostic factors in patients with cholangiocarcinoma.
| Multivariate analysis (Overall Survival) | ||||
|---|---|---|---|---|
| Variable | Category | Odds ratio | p | Confidence interval |
| Histologic Differentiation | well or moderate/poor | 2.266 | 0.040 | 1.038-4.946 |
| T Status | T2/T3 | 1.688 | 0.236 | 0.710-4.009 |
| Overall Tumor Recurrence | negative/positive | 0.011 | 0.0001 | 0.001-0.093 |
| Local Tumor Recurrence | negative/positive | 0.707 | 0.401 | 0.315-1.588 |
| Multiple Tumor Nodules | negative/positive | 0.135 | 0.010 | 0.029-0.623 |
| Tumor size | negative/positive | 0.006 | 0.001 | 0.000-0.137 |
| TEMs in tumor | negative/positive | 2.423 | 0.040 | 1.042-5.633 |
| miR-128 expression | low/high | 38.976 | 0.004 | 3.257-466.374 |
| miR-126 expression | low/high | 0.322 | 0.013 | 0.131-0.789 |
| Multivariate analysis (Recurrence-free Survival) | ||||
| Variable | Category | Odds ratio | p | Confidence interval |
| Tumor Nodules | solitary/multiple | 0.301 | 0.001 | 0.149-0.606 |
| Perineural Sheet Infiltration | negative/positive | 0.370 | 0.008 | 0.178-0.772 |
| Histologic Differentiation | well or moderate/poor | 2.123 | 0.047 | 1.010-4.460 |
| Lymph Node Involvement | negative/positive | 0.542 | 0.066 | 0.282-1.042 |
| TEMs in tumor invasive front | high/low | 2.721 | 0.047 | 1.014-7.302 |
Following clinicopathological parameters were reported previously in the same cohort of patients: histologic differentiation, T status, overall and local tumor recurrence, multiple tumor nodules, tumor size, perineural sheet infiltration and lymph node involvement [37].