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. 2018 Jul 6;9(52):29906–29920. doi: 10.18632/oncotarget.25692

Figure 6. Metformin restricts the existence of coupled E/M- D/U- S/R state.

Figure 6

(A) The (high Notch, high Jagged) region is shifted to higher levels of external EMT-inducer IEXT in presence of metformin (dark purple) compared to the control (i.e. no metformin) case (light purple). (B) The hybrid E/M EMT state is shifted to higher levels of external EMT-inducer IEXT in presence of metformin (dark blue) compared to the control case (light blue). (C) The D/U STEM phenotype is pushed to (high EMT-inducer, high NF-κB) in presence of metformin compared to the control case (dark green vs light green). (D) Metformin enables the existence of a coupled ‘E/M – D/U- S/R’ state only at (high EMT-inducer, high NF-κB) levels (dark orange), as compared to the control case where the ‘E/M- D/U- S/R’ state can exist at (low EMT inducer, low NF-κB) levels (light orange). For this simulation, LEXT = 2000 molecules and the EMT-STEM coupling is intermediate (λLIM−28 = λZEM = 0.5).