Table 4.
Genetic pathways associated with interaction of GPRSMDD and antenatal maternal depressive symptoms in the Asian sample
| Structure | Genetic pathways | Fold enrichment | P-valuea |
|---|---|---|---|
| Interaction of GPRSMDD and antenatal maternal depression | |||
| Right amygdala | Metabotropic glutamate receptor group III | >5 | 0.003 |
| Left OFC and vmPFC | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway |
>5 | 0.004 |
| Histamine H1 receptor-mediated signaling | >5 | 0.005 | |
| Endothelin signaling | >5 | 0.007 | |
| 5-HT2 type receptor-mediated signaling | >5 | 0.013 | |
| Oxytocin receptor-mediated signaling | >5 | 0.044 | |
| Right hippocampus | Axon guidance mediated by Slit/Robo | >5 | 0.027 |
| Alzheimer's disease-amyloid secretase | >5 | 0.047 | |
| Interaction of GPRSMDD and SES | |||
| Right hippocampus | CCKR signaling map | 4.36 | 0.009 |
| 5-HT2 type receptor medicated signaling pathway | >5 | 0.021 | |
| Beta1 adrenergic receptor signaling pathway | >5 | 0.021 | |
| Beta2 adrenergic receptor signaling pathway | >5 | 0.021 | |
Notes: The Fold Enrichment is defined as the ratio of the proportion of our input genes involved in a particular genetic pathway to the proportion of the reference genes involved in the same genetic pathway.
aBonferroni corrected P-value.