Table 1.

Number of variants and SKAT-O association results

Variant category	Minor allele frequency < 0.01		Minor allele frequency < 0.03
	SNPs	P-value	SNPs	P-value
Non-synonymous	432	0.14	446	0.084
CADD > 12.36	294	0.17	300	0.24
Loss of function	10	0.088	10	0.088

Sex and top two principal components were used as covariates in SKAT-O analyses.

CADD ≥ 12.37 corresponds to the predicted 2% most damaging of all possible single-nucleotide changes in the genome. SKAT-O = sequence kernel association test - optimal; SNP = single nucleotide polymorphism; CADD = Combined Annotation Dependent Depletion algorithm.