Table 2.
Logistic Regression Analysis of Characteristics Associated With De-escalation
| Variable | No De-escalation (n = 92), n (%) |
De-escalation (n = 118), n (%) |
P Value | Unadjusted OR (95% CI) | Adjusted OR (95% CI) |
|---|---|---|---|---|---|
| No MRSA, no PA comment | 28 (30) | 77 (65) | <.001 | 4.3 (2.4–7.7) | 5.5 (2.8–10.7) |
| Charlson <3 | 32 (35) | 76 (64) | <.001 | 3.4 (1.9–6.0) | 2.9 (1.5–5.5) |
| APACHE II ≤15 | 36 (39) | 73 (62) | .001 | 2.5 (1.4–4.4) | 2.8 (1.4–5.4) |
| Long term care | 9 (10) | 14 (12) | .632 | 0.8 (0.3–2.0) | 0.4 (0.1–1.0) |
| ≥2 SIRS | 53 (58) | 52 (44) | .052 | 1.7 (1.0–3.0) | Not tested |
| Previous antibiotics | 40 (44) | 57 (48) | .486 | 0.8 (0.5–1.4) | Not tested |
| Hospitalization >48 h | 39 (42) | 51 (43) | .904 | 1.0 (0.6–1.7) | Not tested |
Abbreviations: CI, confidence interval; MRSA, methicillin-resistant Staphylococcus aureus; OR, odds ratio; PA, Pseudomonas aeruginosa; SIRS, systemic inflammatory response syndrome.