Table 3. Drug efficacy against T. cruzi panel strains at 120 h.
pEC50 = –Log (EC50 [M]), average of at least three biological replicates ± SD. Additional data for 72 h and 96 h time points available in S3 and S4 Tables respectively.
| T. cruzi Strain ID | Nifurtimox | Benznidazole | Posaconazole | |||
|---|---|---|---|---|---|---|
| pEC50 | Max inhibition (%) | pEC50 | Max inhibition (%) | pEC50 | Max inhibition (%) | |
| Silvio X10/7 | 6.1 ± 0.2 | 100 ± 1 | 5.7 ± 0.2 | 100 ± 2 | 8.6 ± 0.1 | 97 ± 3 |
| Y | 5.7 ± 0.2 | 103 ± 5 | 4.8 ± 0.1 | 90 ± 4 | 8.6 ± 0.2 | 108 ± 10 |
| M6241 | 6.0 ± 0.1 | 105 ± 5 | 5.5 ± 0.2 | 105 ± 5 | 8.7 ± 0.3 | 104 ± 6 |
| ERA | 6.3 ± 0.0 | 103 ± 3 | 5.9 ± 0.1 | 103 ± 3 | 8.9 ± 0.1 | 91 ± 9 |
| PAH179 | 6.3 ± 0.2 | 102 ± 5 | 5.7 ± 0.1 | 102 ± 5 | <6.0 | 65 ± 14 |
| Tula | 6.3 ± 0.4 | 100 ± 1 | 5.9 ± 0.1 | 99 ± 2 | 8.4 ± 0.1 | 94 ± 5 |
| CLBrener Luc | 6.5 ± 0.1 | 100 ± 2 | 5.9 ± 0.2 | 101 ± 2 | 8.5 ± 0.2 | 94 ± 6 |