Table 3.

Clinical and vascular characteristics of patients with ring finger protein 213 variant-related intracranial major artery stenosis/occlusion

Patient	Gender	Age (year)	Family history of MMD	Vascular risk factors	Clinical symptoms	Manifestation in MRI/CT	Vascular abnormality in CTA/MRA/DSA
1	Male	52	No	Hypertension Smoking Drinking	Dizziness, numbness of the left limbs	Lacunar infarction in the right basal ganglia and corona radiata	Severe stenosis in intracranial vessel of right ICA
2	Male	54	No	Hypertension Smoking Drinking	No symptoms	Infarction in the bilateral centrum semiovale	Moderate stenosis in M1 segment of left MCA
3	Female	45	No	Hypertension	Dizziness	Normal	Occlusion of the left MCA
4	Female	58	No	Hypertension Dyslipidemia	No symptoms	Spotty cerebral ischemic lesions in both lateral ventricles	Severe stenosis of the right MCA with multiple irregular blood vessels in the corresponding level
5	Male	41	No	Smoking Drinking	Weakness of the left limbs	Infarction in the left basal ganglia and left temporal lobe, parietal lobe and insula	Occlusion of the left MCA
6	Female	42	No	Dyslipidemia	Episodic left upper limb numbness and weakness	Spotty cerebral ischemic lesions in right centrum ovale	Occlusion of the right MCA
7	Female	51	No	Dyslipidemia	Dizziness	Normal	Severe stenosis of the right MCA
8	Female	54	No	Hypertension	Episodic weakness in the right limbs	Normal	Severe stenosis in M1 segment of left MCA

ICA: Internal carotid artery, MCA: Middle cerebral artery, CTA: Computed tomography angiography, MRA: Magnetic resonance angiography, DSA: Digital subtraction angiography, MMD: Moyamoya disease, MRI: Magnetic resonance imaging, CT: Computed tomography