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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: J Immunol. 2018 Jun 13;201(3):1073–1085. doi: 10.4049/jimmunol.1800211

Figure 3. Renal proximal tubular TLR9 plays a critical role in ischemic AKI.

Figure 3

A) TLR9fl/fl PEPCK Cre mice and TLR9fl/fl mice were subjected to sham-surgery or to 30 min renal ischemia and 24 hr reperfusion (IR). Plasma BUN and creatinine as well as kidney NGAL mRNA (N=6–8) were measured. B) Global TLR9KO mice had similar increases in plasma BUN and creatinine and kidney NGAL mRNA expression when compared to B6 wild type mice (N=5–7). For statistical analysis, the one-way ANOVA plus Tukey’s post hoc multiple comparison test were used to detect significant changes. *P<0.05 vs. TLR9fl/fl mice subjected to sham surgery. #P<0.05 vs. TLR9fl/fl mice subjected to renal IR. Error bars represent 1 SEM.