Table III.
Cox proportional hazard model results for effect of depression on mortality and amputations: unadjusted hazards, primary model, primary model with interaction for antidepressants.
| Mortality | Amputation | |
|---|---|---|
| HR (95% CI) | HR (95% CI) | |
|
Unadjusted hazards (N=129,157) | ||
| Depression, Yes vs. No | 1.02 (0.99, 1.04) | 1.32 (1.25,1.39) |
|
Primary modela (N=129,157) | ||
| Depression, Yes vs. No | 1.17 (1.14, 1.20) | 1.13 (1.07, 1.19) |
|
Primary modela, with interaction by antidepressant status (N=129,157) | ||
| Depression and Antidepressants interaction | ||
| No Depression, No Antidepressants | Ref. | Ref. |
| No Depression, Antidepressants for other indications | 1.18 (1.16, 1.21) | 1.08 (1.03, 1.14) |
| Depression, Antidepressants | 1.22 (1.19, 1.26) | 1.10 (1.03, 1.17) |
| Depression, No Antidepressants | 1.25 (1.18, 1.33) | 1.42 (1.27, 1.58) |
Abbreviations: HR, hazard ratio; CI, confidence interval.
a
Model adjusting for age at entry into cohort, year of entry into cohort, race, sex, socio-economic status, body mass index, PAD severity (claudication, unspecified, rest pain, ulceration/gangrene), comorbidities [Diabetes mellitus, hypertension, coronary artery disease, congestive heart failure, chronic obstructive pulmonary disease, atrial fibrillation, carotid disease, chronic kidney disease and end stage renal disease], antiplatelet medications, cilostazol, antiglycemics, statins, serum creatinine.