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. Author manuscript; available in PMC: 2019 Oct 15.
Published in final edited form as: Mol Cell Endocrinol. 2018 Feb 8;474:35–47. doi: 10.1016/j.mce.2018.02.005

Figure 9. Schematic representation of the proposed actions of Pyk2 and estrogen on OBs.

Figure 9

We postulate that inhibition of Pyk2 activity increases ERα degradation via the ubiquitin-proteosome pathway, which leads to an increase in ERK signaling and OB proliferation, and consequently promotes OB differentiation and mineralization activity. E2-stimulation, most likely acting through ERβ, has an additive effect on ERK signaling, which further promotes OB activity, leading to an increase in bone formation.