Table I.
Summary of the publications included in the review.
| Literature Reviews (n = 5) | |||||
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| Study reference | Publication type | Design | Methods | Author’s conclusions | |
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| Bassett et al, 2011 | Article | Guideline | Systematic literature review and international 22q11.2DS consensus meetings | Standard management of psychiatric disorders is recommended | |
| Briegel et al, 2004 | Article† | Literature review | Literature review of 22q11.2DS | Standard treatment of psychiatric disorders is recommended | |
| Demily & Franck, 2016 | Article | Literature review | Literature review on idiopathic schizophrenia and 22q11.2DS | It is legitimate to propose CBT in 22q11.2DS | |
| Fung et al, 2010 | Article | Guideline | Systematic literature review and international 22q11.2DS consensus meetings | Standard management of psychiatric disorders is recommended | |
| Gothelf et al, 2013 | Book chapter | Literature review | Literature review ofn 22q11.2DS | Standard management of psychiatric disorders is recommended | |
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| Original research (n = 5) | |||||
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| Study reference | Publication type | Population | Intervention, incentive | Outcome measures | Author’s conclusions |
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| Eliez et al, 2011 | Abstract* (oral) | Intervention group: 28 22q11.2DS, ASD or DD (aged 8-16y), Control group: none | 12-weeks VisAVis; a Computerized software program, Incentive: NR | T-0, T+0 and T+12, Assessments: ‘Cognitive-behavioral evaluations’ (not specified) | VisAVis is a reliable tool for working on socio-emotional impairments in hard-to- treat pediatric populations |
| Eliez and Glaser, 2015 | Abstract* (oral) | Intervention group: 16 22q11.2DS (aged 7-16y) and 19 ASD (aged 7 16 y), Control group: 14 DD (aged 7-16y) | 12-weeks VisAVis Incentive: NR | T-0, T+0 and T12, Assessments: ‘Cognitive-behavioral evaluations’, including Children’s Memory Scale, and Raven Matrices | VisAVis is a useful tool for working on socio-emotional impairments in ASD and 22q11.2DS during middle childhood |
| Harrell et al, 2013 | Article | Intervention group: 13 22q11.2DS (aged 12-17y), Control group: 10 22q11.2DS (aged 12-17y) | 12-weeks, 4 × 40-minute sessions per week, BrainWorks™; an online computerized software program, Incentive: virtual (points) and actual (10 dollars per week), encouraging messages | T-0, T+0 and T+12, Assessments: 7 psychological tests assessing different domains | BrainWorks™ is feasible in children with 22q11.2DS, with high rates of adherence and satisfaction. Preliminary analyses indicate that gains in cognition occur with the intervention |
| Mariano et al, 2015 | Article | Intervention group: 21 22q11.2DS (aged 12-17y), Control group: intervention group served as their own controls | 8-months, 3 × 45-minute sessions per week, Challenging Our Minds; a video conference-based program Incentive: 10 dollar per session | T-32, T-0 and T+0, Assessments: WASI-II, BASC-2 PRS | A computerized CR program may be useful for youth with 22q11.2DS. It appears effective in enhancing cognitive skills during the developmental period of adolescence |
| Shashi et al, 2015 | Article | Intervention group: 13 22q11.2DS (aged 12-17y), Control group: 9 22q11.2DS (aged 12-17y) | 26-weeks, 1 × 60-minute session per week, small-group-based SCT program Incentive: 10 dollar per session attended, reimbursement for mileage | T-0 and T+0, Assessments: 7 psychological tests assessing different domains | SCT in a small-group format for adolescents with 22q11.2DS is feasible and results in gains in social cognition |
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| Other (n = 1) | |||||
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| Study reference | Publication type | Population | Intervention, incentive | Outcome measures | Author’s conclusions |
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| Fjermestad et al, 2015 | Article | Intervention group: 12 22q11.2DS (aged 12-17y), Control group: none | 7 × 45-minute group sessions, during 5 day residential stay, Incentive: NR | NR | Adaptations for interventions in 22q11.2DS are recommended |
22q11.2DS: 22q11.2 deletion syndrome; NR: not reported; CBT: cognitive behavioral therapy; ASD: autism spectrum disorder; DD: developmental delay; T-#: number of weeks pre-intervention; T+#: number of weeks post-intervention; WASI-II: Weschler Abbreviated Test of Intelligence—Second Edition; BASC-2 PRS: The Behavior Assessment System for Children, Second Edition Parent Rating Scale; CR: cognitive remediation; SCT: social cognitive training
†
In German;
*
These two abstracts refer to the same study and overall sample.