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. 2018 Jul 24;8:11167. doi: 10.1038/s41598-018-29504-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MSC from BALf of BOS patients differentially express epigenetic enzymes respect to those of stable LTRs. (a) Non-supervised hierarchical clustering based on the gene expression levels in MSC from BALf of stable LTRs, BOS 0p and BOS (n = 5, n = 2, n = 3, respectively). The dendrogram shows the relationships among gene expression patterns: “red” indicates high relative expression, “black” no change, and “green” low relative expression. Volcano plots showing differentially expressed genes between BOS 0p vs stable LTRs (b), and BOS vs stable LTRs (c). The volcano plot displays statistical significance versus fold-change on the y- and x-axes, respectively. A total of 86 genes were analysed. 17 genes have significantly different expression in MSC from BOS 0p samples respect to controls (p ≤ 0.05): 15 with fold change ≥1.5, and 2 with fold change ≤0.5. Twenty-three genes were significantly upregulated (fold change ≥ 1.5), when comparing the mRNA expression levels between MSC from stable LTRs and BOS samples.