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Diagram summarizing the observed effects and suggested mechanism of PPAR‐γ‐mediated neuroprotection in the MPTPp model of PD. Damaged dopaminergic (DA) neurons activate microglia to assume a M1‐like pro‐inflammatory phenotype with increased release of inflammatory molecules and defective phagocytosis. Administration of the PPAR‐γ agonist boosts phagocytosis and stimulates microglia to acquire an anti‐inflammatory phenotype, therefore resulting in both rescuing and scavenging activity.
