Figure 1.

SFN treatment inhibits thrombosis formation in the inflamed cerebral microcirculation. Light/dye‐induced thrombosis was visualized in the brain and quantified in terms of time taken for complete blood flow cessation. Images taken of thrombus formation in the brain arterioles during light/dye thrombosis events at (A) 0 min, (B) 21 min and (C) 29 min when blood flow cessation occurred. Values represent time to flow cessation following light/dye injury in cerebral (D) arterioles and (E) venules. Animals were treated with SFN (5 or 50 mg·kg⁻¹) or vehicle 24 h prior to inflammatory challenge with LPS (0.5 mg·kg⁻¹). Bar = 10 μm. Data are mean ± SEM of 6 mice per group with one to three vessels analysed per mouse. ^* P < 0.05 versus vehicle control. ⁺ P < 0.05 versus LPS treated group.