Figure 4.

SFN reduces collagen‐induced platelet aggregation in vivo. A thromboembolic in vivo model was used to measure platelet aggregation in mice treated with SFN (10 mg·kg⁻¹) or vehicle saline (V) for 30 min prior to an i.v. injection of collagen (50 μg·kg⁻¹). Platelet aggregation was measured by changes in platelet‐associated radioactivity (10 min), and data are represented as (A) maximum % increase in platelet counts, (B) AUC and (C) % of change in platelet counts. Data are mean ± SEM of n = 5 mice per group; ^* P < 0.05 versus saline vehicle treated group. ⁺ P < 0.05 versus collagen stimulated vehicle group.