Figure 6.

SFN treatment reduces collagen and vWF mediated collagen platelet adhesion under conditions of physiological flow. (A and B) Human platelets were perfused over collagen‐coated flow chambers at a shear stress of 1 dyne·cm⁻² (0.1 Pascal) for 10 min before imaging, SFN treatments were given 30 min prior to flow. (C and D) Collagen coated flow chambers were pretreated with vWF (2 μg·mL⁻¹) before perfusion of platelets at a shear stress of 5 dyne·cm⁻² (0.5 Pascal), and SFN given 30 min prior to flow. Data are mean ± SEM of n = 5 independent donors per group. ^* P < 0.05 versus vehicle treated in the absence of vWF. ⁺ P < 0.05 versus vWF treated vehicle group.