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Proposed mechanism for the induction of MT1 receptors by VPA. VPA activates the transcription of MT1 receptors by causing chromatin remodelling, mediated by HDAC inhibition and MT1 promoter hyperacetylation. VPA also acts via intracellular kinases to regulate the expression of transcription factors that control the activity of the MT1 promoter, suggesting a role for this drug in the transcriptional kinetics of MT1 receptor expression.
