Table 3.
Summary of the independent genome-wide significant SNPs from meta-analysis of 2016 IHGC migraine and 2016 23andMe MDD GWAS
| SNP | Chr | Position | RefSeq gene context | EA | NEA | FE meta-analysis | Migraine | MDD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | P value | OR | P value | OR | P value | ||||||
| rs12127789 | 1 | 72740073 | [NEGR1] | T | G | 1.05 | 7.20 × 10−9 | 1.04 | 0.015 | 1.05 | 1.67 × 10−7 |
| rs2195636 | 3 | 158352440 | MLF1-[]-GFM1 | T | C | 1.03 | 1.42 × 10−8 | 1.02 | 0.048 | 1.04 | 5.63 × 10−8 |
| rs768705 | 5 | 87568710 | [TMEM161B‒AS1] | A | G | 0.97 | 1.52 × 10−8 | 1.01 | 0.22 | 0.95 | 6.58 × 10−13 |
| rs146377178 | 8 | 25386973 | CDCA2-[]--EBF2 | T | C | 1.09 | 7.41 × 10−9 | 1.09 | 4.24 × 10−3 | 1.09 | 6.13 × 10−7 |
| rs6476606 | 9 | 37005561 | [PAX5] | A | G | 1.03 | 2.52 × 10−8 | 1.04 | 2.98 × 10−4 | 1.03 | 1.50 × 10−5 |
| rs672931 | 11 | 30920897 | [DCDC1] | T | C | 1.03 | 7.01 × 10−9 | 1.04 | 8.27 × 10−4 | 1.03 | 2.34 × 10−6 |
| rs9536359 | 13 | 53691446 | OLFM4--[]-LINC01065 | T | C | 0.96 | 2.75 × 10−13 | 0.97 | 3.88 × 10−3 | 0.96 | 1.15 × 10−11 |
| rs11858956 | 15 | 70261228 | RPLP1--[]-TLE3 | T | C | 0.97 | 4.20 × 10−8 | 0.97 | 3.51 × 10−3 | 0.97 | 3.27 × 10−6 |
| rs5751069 | 22 | 41627775 | [CHADL] | C | G | 0.96 | 5.42 × 10−11 | 0.96 | 4.58 × 10−4 | 0.96 | 2.51 × 10−8 |
SNP dbSNP v147 variant ID, Chr chromosome, Position hg19 human genome assembly, RefSeq gene context for genic SNPs, the relevant gene is listed within brackets and for intergenic SNPs the genes flanking the locus are listed, EA effect allele, NEA non-effect allele, FE meta-analysis fixed effect model meta-analysis, OR odds ratio for the EA, Migraine 2016 IHGC migraine GWAS, MDD 2016 23andMe MDD discovery GWAS