Table 5.

Genome-wide significant genes in gene-based associations with 2016 IHGC migraine and 2013 PGC MDD

Gene	Chr	Gene position	Fisher’s combined P value (gene-based P value for migraine and MDD)	Top SNP	EA	NEA	Top SNP position	Migraine		MDD
								OR	P value	OR	P value
ANKDD1B	5	74907284–74967671	1.57 × 10-6 (1.81 × 10-6; 0.0050)	rs34358a	A	G	74965122	0.94	1.49 × 10-7	1.02	0.38
				rs904743a	A	G	74917862	0.97	0.039	1.09	4.30 × 10-3
KCNK5	6	39156747–39197251	1.39 × 10-7 (7.59 × 10-8; 0.093)	rs9394578b	C	A	39165859	0.93	3.97 × 10-9	1.03	0.23
				rs2815095b	C	T	39156108	0.95	1.34 × 10-5	1.07	4.90 × 10-3

Chr chromosome, Gene Position hg19 human genome assembly, Fisher’s combined P value gene-based association P value from Fisher’s combined P value test with the specific gene-based association P value for migraine and MDD (respectively) shown in brackets, Top SNP the most significant SNP assigned to the gene in the 2016 IHGC migraine GWAS and 2013 PGC MDD GWAS, EA Top SNP effect allele, NEA Top SNP non-effect allele, Top SNP position hg19 human genome assembly, Migraine 2016 IHGC migraine GWAS, MDD 2016 23andMe MDD discovery GWAS, OR odds ratio for EA,

^aLinkage disequilibrium between rs34358 and rs904743 is weak (r² = 0.24),

^bLinkage disequilibrium between rs9394578 and rs2815095 is weak to moderate (r² = 0.39).