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. 2018 Jul 25;7:133. doi: 10.1038/s41426-018-0136-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Data are shown as box-and-whisker diagrams. The box represents the interquartile range (IQR) between the 25th (Q1) and 75th (Q3) percentiles and includes a median line. Lower and upper whiskers represent Q1−1.5 × IQR and Q3 + 1.5 × IQR, respectively. Open data points show extreme outliers. WU, World Health Organization units