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. 2018 Jul 24;9:2893. doi: 10.1038/s41467-018-05125-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — GluACTPs differentially affect dendritic arbor growth in excitatory and inhibitory neurons. a, b Representative images of excitatory (a) and inhibitory (b) neurons. Left panel: Example of the live image and reconstructed full dendritic arbor of an individual neuron (top). Post hoc GABA immunolabeling (bottom) of the same neuron. Green, GFP; gray/magenta, GABA. Scale bar: left 100 μm; middle and right 10 μm. Right panel: Representative live images (top) of inhibitory neurons expressing GFP only (control), GluA1CTP, or GluA2CTP, and reconstructed complete dendritic arbors (bottom). c, d Summary data of total dendritic branch length (TDBL), total branch tip number (TBTN), and branch density control, GluA2CTP- and GluA1CTP-expressing excitatory (c) and inhibitory (d) neurons. *P < 0.05, Kruskal–Wallis test with post hoc Mann–Whitney U test. Number of neurons in each group is shown in the graph. e, f Sholl analysis: neither GluA1CTP nor GluA2CTP affected dendritic arbor branching pattern in excitatory neurons (e). GluA2CTP but not GluA1CTP significantly increased branch density distal to the soma in inhibitory neurons (f) compared to controls. *P < 0.05, **P < 0.01, Kruskal–Wallis test with post hoc Mann–Whitney U test