Table 2.
Results of microdialysis measured by ISCUS for Patients A-H.
| Metabolite | Condition | A | B | C | D | E | F | G | H | Mean change |
|---|---|---|---|---|---|---|---|---|---|---|
| L/P ratio | Baseline | 16.3 | 45.1 | 16.0 | 20.2 | 12.5 | 26.4 | 18.1 | 29.0 | −13% p < 0.0001 |
| Succinate | 11.5 | 28.4 | 14.1 | 18.4 | 11.8 | 26.5 | 20.6 | 21.4 | ||
| % change | −29.6 | −37.1 | −12.1 | −8.8 | −5.2 | +0.6 | +14.0 | −26.4 | ||
| Glucose (mM) | Baseline | 2.7 | 1.3 | 1.9 | 2.6 | 3.4 | 1.5 | 1.6 | 1.5 | −5% p = 0.1 |
| Succinate | 3.2 | 1.1 | 1.8 | 1.1 | 3.7 | 1.9 | 1.3 | 1.7 | ||
| % change | +16.6 | +11.3 | −6.1 | −58.1 | +7.4 | +23.9 | −20.5 | +10.3 | ||
| Lactate (mM) | Baseline | 4.0 | 3.1 | 1.7 | 6.3 | 1.2 | 6.5 | 1.6 | 2.0 | +6% p = 0.08 |
| Succinate | 3.6 | 3.2 | 1.8 | 2.9 | 1.4 | 7.1 | 2.2 | 2.7 | ||
| % change | −9.9 | +2.1 | +6.2 | −53.4 | +13.0 | +8.9 | +41.6 | +36.7 | ||
| Pyruvate (μM) | Baseline | 244 | 70 | 105 | 313 | 99 | 247 | 81 | 76 | +26% p < 0.0001 |
| Succinate | 313 | 112 | 133 | 170 | 118 | 268 | 108 | 134 | ||
| % change | +28.4 | +60.9 | +26.4 | −45.6 | +19.2 | +8.1 | +33.8 | +75.9 |
Mean results of microdialysis samples analysed with ISCUS during baseline perfusion with normal perfusion fluid or a period with succinate supplemented perfusion fluid. L/P ratio: lactate/pyruvate ratio, mM: millimole/litre, μM: micromole/litre. p-values from analysis of pooled results using the package lmer in R, (significance <0.05 denoted by bold font) - see Methods subsection Statistical analysis for further details.