Table 3.
PCr/γATP ratio results from 31P MRS analysis of frontal voxels supplemented with succinate, compared simultaneously to their contralateral unsupplemented voxels.
| Subject I.D. | PCr/γATP ratio Unsupplemented (contralateral) voxel | PCr/γATP ratio Succinate-supplemented voxel | Percentage difference |
|---|---|---|---|
| A | 0.871 | 1.528 | +75.5% |
| B | 1.089 | 1.270 | +16.6% |
| C | 1.086 | 1.136 | +4.6% |
| D | 1.050 | 1.082 | +3.1% |
| E | 1.134 | 1.000 | −11.9% |
| F | 1.293 | 1.135 | −12.2% |
| G | 0.967 | 0.963 | −0.4% |
31P MRS measurements of PCr/γATP in the frontal voxels of the seven patients who received succinate supplementation. Each voxel that received succinate was matched with a partner contralateral frontal voxel that did not receive supplementation, within the same patient. The difference in PCr/γATP between supplemented and matched unsupplemented voxels was not statistically significantly different (two-tailed Wilcoxon signed rank test p = 0.58). An eight patient (H) also underwent 31P MRS but yielded no useable data due to low signal-to-noise.