Fig. 1.

Distribution and type of germline variants occuring along the SMARCB1 gene. On the left side, variants causing benign entities are indicated in violet (schwannoma), yellow (meningioma), and green (Coffin–Siris syndrome), while the right side shows malignancies in red (rhabdoid tumor) and light blue (CRINET). Red bars show extent of deletions and duplications. Note that variants in benign disorders are mainly present in 1, 2, 8, and 9, while malignant tumors are frequently caused by variants within exons 2–7. Light blue bars indicate for known domains