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. 2018 Jul 24;9(8):809. doi: 10.1038/s41419-018-0849-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Tumor volume changes over time in mice bearing 4T1 allografts following treatment with GDC-0941 (125 mg/kg/day, oral gavage) and Aspirin (100 mg/kg/day, oral gavage) as single agents or in combination (n = 5–6 per treatment group). Error bars represent mean ± S.E.M. b Changes in body weight of 4T1 tumor-bearing mice during 21 days treatments with GDC-0941 (125 mg/kg/day, oral gavage) and Aspirin (100 mg/kg/day, oral gavage) as single agents or in combination (n = 5–6 per treatment group). Error bars represent mean ± S.E.M. c Representative images of histological staining for 4T1 tumors from Balb/c mice (n = 5 per treatment group) following treatment with GDC-0941 and Aspirin as single agents or in combination for 4 days. Scale bar, 200 μm. d Representative images of immunohistochemical staining for proteins as indicated in 4T1 tumors from Balb/c mice (n = 5 per treatment group) following treatment with GDC-0941 and Aspirin as single agents or in combination for 4 days. Scale bar, 50 μm. Data are shown as mean ± S.E.M. e Representative images of gross examination (upper panel) and histological staining (lower panel) of lung metastasis in mice bearing 4T1 tumors treated with GDC-0941 and Aspirin as single agents or in combination (n = 5 per treatment group) for 21 days. Scale bar, 200 μm. The numbers of lung metastatic nodules per mouse are shown as mean ± S.E.M. *P < 0.05; **P < 0.01; ***P < 0.001 (Student’s t-test)