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GALNT14 regulates the stability of P-gp. MCF-7 expressing GALNT14 (A) or MCF-7/ADR cells treated with shRNA-GALNT14 (B) were further treated with 50 μg/ml of cycloheximide (CHX) for indicated hours. Western blots were performed with anti–P-gp antibody to examine the stability of P-gp. GAPDH served as loading controls. (C) A model to show the mechanism by which the upregulated GALNT14 promotes MDR.
