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. 2018 Jul 18;9:771. doi: 10.3389/fphar.2018.00771

FIGURE 5.

FIGURE 5

Effect of BC and/or SG on insulin signaling pathway (p-IR/p-AKT/GLUT4) in the skeletal muscle. Effect of 2 weeks daily administration BC (20 mg/kg, i.p), SG10, SG20 (10 and 20 mg/kg, p.o) and their combination (BC + SG10) on soleus skeletal muscle content of (A) p-IR, (B) p-AKT, and (C) GLUT4 in HF/Fr/STZ diabetic rats. Values are means of 6–10 rats ± SD. As compared with normal control (NC; ∗), diabetic control (DC; @), BC (#), SG10 ($), and SG20 (Ω) treated groups (one-way ANOVA followed by Newman–Keuls multiple comparison test) at P < 0.05. BC, bromocriptine; SG, sitagliptin; p-IR, phosphorylated insulin receptor [pYpY1162/1163]; p-AKT, phosphorylated protein kinase B [pS473]; GLUT4, glucose transporter 4.