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. 2018 Jul 18;9:771. doi: 10.3389/fphar.2018.00771

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Copyright © 2018 Reda, Hassaneen and El-Abhar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of BC and/or SG on PPAR-γ/Adiponectin signaling in the skeletal muscle. Effect of 2 weeks daily administration BC (20 mg/kg, i.p), SG₁₀, SG₂₀ (10 and 20 mg/kg, p.o) and their combination (BC+SG₁₀) on soleus skeletal muscle content of (A) PPAR-γ and (B) serum adiponectin in HF/Fr/STZ diabetic rats. Values are means of 6–10 rats ± SD. As compared with normal control (NC; ^∗), diabetic control (DC; @), BC (#), SG₁₀ ($), and SG₂₀ (Ω) treated groups (one-way ANOVA followed by Newman–Keuls multiple comparison test) at P < 0.05. BC, bromocriptine; SG, sitagliptin; PPAR-γ, peroxisome proliferators-activated receptor gamma.