Table 1.
Functional overrepresentation of gene ontology (GO):BP terms in panther.
| GO biological process complete | Background set | Network set | Network fold enrichment | AdjustedP-value | Network genes |
|---|---|---|---|---|---|
| Control vs 0 days | |||||
| Lymphocyte chemotaxis (GO:0048247) | 34 | 8 | 69.26 | 5.14E−09 | Adam8, Ccl2, Cxcl16, Cxcl11, Ccl12, Ccl7, Ccl22, Ccl17 |
| T cell migration (GO:0072678) | 19 | 4 | 61.97 | 6.73E−03 | Ccl2, Cxcl16, Cxcl11, Itgb7 |
| Lymphocyte migration (GO:0072676) | 45 | 9 | 58.87 | 7.12E−10 | Adam8, Ccl2, Cxcl16, Cxcl11, Ccl12, Ccl7, Itgb7, Ccl22, Ccl17 |
| Monocyte chemotaxis (GO:0002548) | 30 | 6 | 58.87 | 1.24E−05 | Anxa1, Ccl2, Ccl12, Ccl7, Ccl22, Ccl17 |
| Mononuclear cell migration (GO:0071674) | 33 | 6 | 53.52 | 2.18E−05 | Anxa1, Ccl2, Ccl12, Ccl7, Ccl22, Ccl17 |
| Granulocyte chemotaxis (GO:0071621) | 65 | 7 | 31.7 | 3.38E−05 | Anxa1, Ccl2, Spp1, Ccl12, Ccl7, Ccl22, Ccl17 |
| Neutrophil chemotaxis (GO:0030593) | 58 | 6 | 30.45 | 6.00E−04 | Ccl2, Spp1, Ccl12, Ccl7, Ccl22, Ccl17 |
| Granulocyte migration (GO:0097530) | 71 | 7 | 29.02 | 6.17E−05 | Anxa1, Ccl2, Spp1, Ccl12, Ccl7, Ccl22, Ccl17 |
| Chemokine-mediated signaling pathway (GO:0070098) | 61 | 6 | 28.95 | 8.05E−04 | Ccl2, Cxcl11, Ccl12, Ccl7, Ccl22, Ccl17 |
| Neutrophil migration (GO:1990266) | 63 | 6 | 28.03 | 9.72E−04 | Ccl2, Spp1, Ccl12, Ccl7, Ccl22, Ccl17 |
| Control vs 3 days | |||||
| Regulation of chromosome segregation (GO:0051983) | 86 | 6 | 19.99 | 6.93E−03 | Ube2c, Dusp1, Pttg1, Knstrn, Bub1b, Spag |
| Mitotic sister chromatid segregation (GO:0000070) | 95 | 6 | 18.1 | 1.23E−02 | Aurk, Pttg1, Knstrn, Kiff22, Cxc20, Spag5 |
| Mitotic nuclear division (GO:0140014) | 131 | 8 | 17.5 | 2.38E−04 | Ube2c, Aurkb, Pttg1, Knstrn, Tpx2, Kiff22, Cdc20, Spag5 |
| Sister chromatid segregation (GO:0000819) | 119 | 7 | 16.86 | 2.42E−03 | Ube2c, Pttg1, Knstrn, Bub1b, Kif22, Cdc20, Spag5 |
| Spindle organization (GO:0007051) | 122 | 7 | 16.44 | 2.86E−03 | Ube2c, Cep72, Knstrn, Stmn1, Tpx2, Cdc20, Spag5 |
| Nuclear division (GO:0000280) | 263 | 11 | 11.99 | 2.35E−05 | Ube2c, Aurkb, Rad51, Pttg1, Knstrn, Bub1b, Tpx2, Kiff22, Cdc20, Spag5 |
| Regulation of nuclear division (GO:0051783) | 170 | 7 | 11.8 | 2.55E−02 | Ube2c, Tnf, Dusp1, Pttg1, Bub1b, Cdc20, Ifg1 |
| Mitotic cell cycle process (GO:1903047) | 395 | 16 | 11.61 | 5.61E−09 | Ube2c, Aurkb, Iqgap3, Rad51, Kif20a, Pttg1, Knstrn, Bub1b, Stmn1, Cdkn3, Tpx2, Kiff22, Ier3, Cdc20, Spag5 |
| Mitotic cell cycle (GO:0000278) | 457 | 18 | 11.29 | 2.58E−10 | Ube2c, Aurkb, Iqgap3, Nuf1, Rad51, Kif20a, Pttg1, Cenpw, Knstrn, Bub1b, Stmn1, Cdkn3, Tpx2, Kiff22, Ier3, Cdc20, Spag5 |
| Organelle fission (GO:0048285) | 294 | 11 | 10.72 | 7.35E−05 | Ube2c, Aurkb, Rad51, Pttg1, Knstrn, Bub1b, Tpx2, Kif22, Cdc20, Spag5 |
| Control vs 7 days | |||||
| Antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 29 | 4 | 46.22 | 2.11E−02 | RT1-T24-4, RT1-CE10, RT1-CE5, RT1-CE5 |
| Antigen processing and presentation of peptide antigen (GO:0048002) | 47 | 6 | 42.78 | 7.93E−05 | RT1-T24-4, RT1-CE10, RT1-CE5, Cd74, RT1-CE5, RT1-Da |
| Antigen processing and presentation (GO:0019882) | 79 | 6 | 25.45 | 1.66E−03 | RT1-T24-4, RT1-CE10, RT1-CE5, Cd74, RT1-CE5, RT1-Da |
| Cell adhesion (GO:0007155) | 654 | 11 | 5.64 | 3.79E−02 | Itgae, Tnf, Gpnmb, Axl, Rom1, Cd63, Mfge8, Cldn1, Lgals3bp, Cdh17, Cd96 |
| Biological adhesion (GO:0022610) | 663 | 11 | 5.56 | 4.32E−02 | Itgae, Tnf, Gpnmb, Axl, Rom1, Cd63, Mfge8, Cldn1, Lgals3bp, Cdh17, Cd96 |
| Immune response (GO:0006955) | 798 | 13 | 5.46 | 6.23E−03 | Fut7, Tnf, RT1-T24-4, Cfb, Cxcl13, Cldn1, RT1-CE5, Cd74, Cdh17, RT1-CE5, Skap1, RT1-Da |
| Cell surface receptor signaling pathway (GO:0007166) | 1,591 | 18 | 3.79 | 6.48E−03 | Itgae, Tnf, Card14, Axl, Csf2ra, Sulf1, Evc, Rom1, Cd63, Adgre5, Cxcl13, PLxnc1, Cxcr6, Cxcr3, Cd74, Cdh17, Cd3e, Skap1 |
| Immune system process (GO:0002376) | 1,607 | 18 | 3.75 | 7.50E−03 | Ctnnbl1, Fut7, Tnf, Axl, RT1-T24-4, Cfb, Ifitm1, Cxcl13, Cldn1. RT1-CE10. Cxcr3, RT1-CE5, Cd74, Cdh17, RT1-CE5 Cd3e, Skap1, RT1-Da |