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. 2018 Jul 18;12:140. doi: 10.3389/fnbeh.2018.00140

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Copyright © 2018 Torres, Akinyeke, Stagaman, Duvoisin, Meshul, Sharpton and Raber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Home cage activity of wild-type (WT; A,C) and knockout (KO; B,D) during the light (A,B) and dark (C,D) periods during the treatment period. (A,B) WT and KO mice showed less activity during the second week of treatment (WT: p < 0.001; KO: p < 0.001). KO female mice moved more during the light cycle than KO males. ^ap = 0.019. (C,D) During the dark cycle, WT and KO mice showed a similar decrease in activity during week 2 (WT: p = 0.004; KO: p < 0.001) that was affected by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. WT: ^{^}p < 0.001; KO: ^{^}p = 0.001. WT and KO females moved more than males; WT: ^ap = 0.005; KO: ^ap < 0.001. KO females also moved less during week 2 than KO males. ^#p = 0.015.